The main injury here is that the Saints will be without top running back Alvin Kamara once again. The veteran is out with knee and ankle injuries in this divisional clash with the Panthers, who can take first place in the NFC South with a win thanks to Tampa Bay's loss on Thursday.

The Dallas Cowboys receiver was injured during last week's loss to the Detroit Lions when he went up for a deep pass in the end zone and was contorting his body trying to make a one-handed catch. He couldn't make the catch and then landed hard and his head slammed on the ground.

Christian McCaffrey is still one of the 49ers' best operators.

Christian McCaffrey and Saquon Barkley lead UPI senior sports writer Alex Butler's Top-50 fantasy football running back rankings for Week 15.

Trent Williams aims to help his San Francisco 49ers teammate Christian McCaffrey hit another 1,000-1,000 season in 2025.

McCaffrey said the best part of his bye was playing with his five-month-old daughter, Colette, but he also rested and recovered after 322 combined rushes and receptions in the first 13 games. With five catches against the Titans on Sunday, McCaffrey would become the first running back in NFL history with at least 90 receptions in three seasons.