As the 49ers prepare for Sunday’s matchup against the Tennessee Titans, McCaffrey’s availability has become a storyline. Earlier in the week, he battled an illness that limited his practice time, though he was able to log a full session on Friday.

The San Francisco 49ers have placed receiver Brandon Aiyuk on the reserve/left squad list, making him ineligible to return from a knee injury this season.

Christian McCaffrey (back) has been added to the team's injury report and is listed as questionable for Sunday's game.

The San Francisco 49ers on Saturday placed Brandon Aiyuk on the reserve/left squad list, ending his 2025 season and likely severing the team’s ties with the talented wide receiver for the future.

The San Francisco 49ers added running back Christian McCaffrey gave fans quite a scare on Saturday by adding him to the injury report. However, ESPN's Adam Schefter and Nick Wagoner reported on Saturday that he should be good to play despite his questionable designation for a back issue.

The San Francisco 49ers could face a major setback when the 2025 NFL season ends, as Robert Saleh might be on a team's radar for head coach.

So if the Niners let him play out his contract, shake his hand, and watch him sign a solid $20-to-$30 (maybe $40) million-dollar deal elsewhere in free agency come the end of the 2026 season, the league office will essentially FedEx a third-round pick (fourth at worst) to Santa Clara. That’s money in the bank. That’s a free lottery ticket.

The San Francisco 49ers are doing so well in 2025 that they probably won't make a pick until later in the first round in the 2026 NFL draft.