A team of researchers from Academia Sinica and National Taiwan University has identified the Drosophila Cul2 substrate adaptor DmZer1 as a key regulator of protein quality control, acting at the ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

Deep inside nearly every cell, a molecular cleanup crew works around the clock to keep the interior tidy. One of its most ...

In a recent study published in the journal Neuron, researchers at the University of Cambridge and Newcastle University, UK, examined the relationship between autophagy, aging, and neurodegeneration.

A 2026 review identifies shared pathways involving synapses, immunity, metabolism, epigenetics and waste clearance in autism ...

A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel therapeutic target. AD, a representative form of senile dementia, occurs ...

A complex cellular process called autophagy is the topic of a major new textbook which encapsulates over 30 years of research in this growing field of study. A complex cellular process called ...

Human genetic and mechanistic studies reveal thousands of pathogenic proteins that may serve as potential targets for small-molecule drugs. Meanwhile, the conventional method of drug discovery through ...

Altered dopaminergic neurotransmission underlies a variety of neurological and neuropsychiatric diseases, including playing a central role in the neurodegenerative processes that lead to Parkinson’s ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...