No. 6 Louisville comes into a matchup against NJIT after winning five home games in a row. The teams meet Wednesday for the first time this season.

The Arizona Cardinals, losers of seven of their last eight games, hope to regroup against a tough Jacksonville Jaguars team. The 3-7 Cardinals and 6-4 Jaguars kick off from State Farm Stadium at 4:05 p.m. ET (2:05 p.m. Arizona time). The Jags have won two of three and are coming off a 35-6 win over the LA Chargers.

The Jaguars are 5-4-1 against the spread, while the Cardinals are 5-5 ATS. Arizona has the 14th-best offense and 21st best defense, while Jacksonville has the 19th-best offense and14th-best defense. Jaguars vs. Cardinals score prediction: Jaguars 26, Cardinals 23

Even though the Arizona Cardinals have only played one game on Thanksgiving, the franchise has an extensive history of playing on the holiday.

Trevor Lawrence and the Jacksonville Jaguars head west to meet Jacoby Brissett and the Arizona Cardinals. Follow the Times-Union's live updates.

The Jacksonville Jaguars face the Arizona Cardinals on Sunday, Nov. 23, 2025 at State Farm Stadium in Glendale, Arizona.

Quarterback Brock Purdy is finally returning from injury and will start for the 49ers in Week 11 against the Cardinals.

The post Packers latest roster updates will catch fans’ attention before Cardinals game appeared first on ClutchPoints. The Green Bay Packers are heading to the road for consecutive games away from Lambeau Field in Weeks 7 and 8 against the Arizona ...