The process of DNA replication relies on the coordinated action of a ring‐shaped sliding clamp and its specialised loader complexes. Sliding clamps, typified by proliferating cell nuclear antigen ...

DNA replication is a complex process with many moving parts. In baker's yeast, the molecular complex Ctf18-RFC keeps parts of the replication machinery from falling off the DNA strand. Human cells use ...

Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, actually plays a key role in ensuring fast and reliable replication—an insight ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every time a cell divides, the complete code, divided among 46 chromosomes, must ...

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals Science ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...

Replication origins in Trypanosoma brucei integrate multiple features previously described individually in opisthokonts, revealing a unified structural topology built from strand-specific nucleotide ...

A research team at the University of Würzburg has deciphered another aspect of poxviral gene activation. The study reveals a unique viral mechanism: a molecular ring anchors the viral copying machine ...

A research team at the University of Würzburg has deciphered another aspect of poxviral gene activation. The study reveals a unique viral mechanism: a molecular ring anchors the viral copying machine ...