Cells have sophisticated methods of sensing stimuli and communicating with nearby cells in response to these stimuli. For example, macrophages can sense environmental stimuli—tissue damage, foreign ...

Autoimmune diseases result from a complex interaction of immune system imbalances, marked by a breakdown in self-tolerance and sustained inflammation. At the core of this dysregulation are ...

Alveolar fibroblasts play a key role in regulation of lung inflammation. Pseudomonas aeruginosa (PAO) is one of the most ...

Cytokines are a large group of bioactive small molecule proteins synthesized and secreted by immune and non-immune cells. There are various types of cytokines that belong to different families and ...

Rheumatoid arthritis (RA) is a common autoimmune disease in which the immune system recognizes autoantigens on otherwise healthy joint tissues as foreign invaders, inducing a localized inflammatory ...

People often get immunotherapy as a treatment for cancer. These immunotherapy treatments can be effective, but they may cause your immune system to have an unnatural response. Your body, as a result ...

Sanofi’s work with engineered cytokines has stumbled in the clinic, but the company isn’t throwing in the towel yet on such therapies, which hold potential for treating autoimmune diseases and cancer.

For patients with lymphoma or multiple myeloma, speaking up about symptoms of cytokine release syndrome can be lifesaving. It’s important for patients receiving bispecific antibodies for lymphoma or ...