The ceremony will broadcast live at 9 p.m. ET on April 23 via Telemundo.
"Remember, a smile can change and even save a life," said the Mexican icon who received the Lifetime Achievement award.
The Puerto Rican star received the Imparable Award from Villano Antillano.
Karol G closed out Coachella with an explosive set filled with Latin and female empowerment, and guests Becky G, Wisin,Arturo Sandoval and more.