The EMBO Journal5d
A CRISPR-Cas9 screen reveals genetic determinants of the cellular response to decitabine
A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...
The EMBO Journal5d
Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer
Aneuploidy is frequent in cancer, but in vitro it triggers multiple cellular stresses and often delays proliferation. Through ...
The EMBO Journal5d
Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cancers display cellular, genetic and ...
The EMBO Journal17d
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Ferroptosis, an iron-dependent form of ...
The EMBO Journal5d
Pharmacological CDK4/6 inhibition promotes vulnerability to lysosomotropic agents in breast cancer
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Breast cancer is a leading cause of mortality ...
The EMBO Journal9d
Microbial metabolites tune amygdala neuronal hyperexcitability and anxiety-linked behaviors
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Changes in gut microbiota composition have ...