On Friday night, Kentucky Sen. Mitch McConnell strode onto the Senate floor and, without a moment’s hesitation, voted against the Republican president’s nominee for secretary of defense. The vote marked the hard launch of a new, unburdened, and final chapter in McConnell’s 40-year Senate career.

The Republican senator’s childhood bout with the disease has informed his ardent support for vaccines amid increasing skepticism of them within his party.

Several Kentucky lawmakers and organizations are expressing concern over the Trump administration's decision to pause federal grants, loans and other financial assistance programs.

The Senate just barely confirmed Pete Hegseth as Defense Secretary last week. Mitch McConnell’s vote against him in particular could spell trouble for Trump's shakiest nominees, including Robert F. Kennedy Jr,

After weeks of speculation, Kentucky Sen. Mitch McConnell voted Thursday to put Pete Hegseth on the brink of confirmation to become the nation’s next defense secretary. The procedural vote of 51-49 put the Fox News host on the path for approval Friday ...

After a few GOP senators, including McConnell, voted against Hegseth for defense secretary, the Senate narrowly voted to confirm him.

"McConnell spent his life creating this crisis...Only at the end does he find a conscience," political commentator Wajahat Ali wrote.

LOUISVILLE, Ky. (WDRB) — Mitch McConnell, the longest-serving senator from Kentucky, will not be at the helm of the Senate as he finishes his term, but political analysts say his influence is far from diminished.

We shouldn’t expect McConnell to be the next John McCain or Mitt Romney, but his vote Friday against Pete Hegseth previewed some fascinating dynamics ahead.

Sen. Mitch McConnell of Kentucky voted against President Donald Trump's nominee to be secretary of defense, Pete Hegseth.

"Trump just jeopardized basic programs that Kentuckians depend on to survive — from SNAP to LIHEAP. This unprecedented and reckless order will inflict unimaginable pain across Kentucky. Call KY Republicans in Congress NOW and tell them to stand up for families: (202) 224-3121."

McConnell's vote of conscience against Pete Hegseth, following decades of obstruction, was rendered meaningless after J.D. Vance broke the tie vote.