Head coach Kyle Shanahan of the San Francisco 49ers looks on during warmups before the game against the Arizona Cardinals at State Farm Stadium on Nov. 16, 2025 in Glendale, Ariz. A costly penalty by a San Francisco 49ers defensive player led head coach Kyle Shanahan to bench him and confront him on the sidelines.

Glendale, AZ -- The 49ers just blew out the Arizona Cardinals 41-22. Granted, the Cardinals got blown out last week too and now have lost 7 of their past 8 games since they lost to Mac Jones and the 49ers in Week 3. They're dead. They need to fire their head coach.

The San Francisco 49ers picked off Arizona's Jacoby Brissett twice, a defensive counter to the QB's NFL record 47 completions. Said Malik Mustapha: "Little dink and dunks."

The San Francisco 49ers crushed the Cardinals in Brock Purdy's return to action, but that was expected. New injuries and some of the same old problems remain for this team's playoff hopes.

An injured Kyler Murray, a depleted backfield and really, inconsistent football. It didn’t stop today either in their loss to the San Francisco 49ers in Week 11. Let’s take a look at some key stats that led to the Cardinals' seventh loss of the season:

The San Francisco 49ers are already without Fred Warner, and they may have lost another linebacker early against the Arizona Cardinals on Sunday.

Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from November 16, 2025 on ESPN.

Learn which TV channel or how to live stream the NFL Week 11 Arizona Cardinals and San Francisco 49ers game, Sunday, Nov. 16.

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