President Donald Trump has issued a number of executive orders (EO) focused on healthcare for people who identify as lesbian, gay, bisexual, transgender, queer, or other sexual or gender minority.
Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
In a deal worth approximately $935 million, Jazz Pharmaceuticals will acquire the biopharmaceutical company Chimerix. Jazz will now own Chimerix’s leading drug, dordaviprone, a novel first-in-class ...
The EZH2 inhibitor mevrometostat, in combination with the androgen receptor signaling inhibitor enzalutamide, improved progression-free survival and objective response rates in patients with ...
Cancer Grand Challenges, Cancer Research UK, London, United Kingdom.
Most anti-PD1/PD-L1 antibodies have exhibited poor efficacy in some clinical indications, primarily due to insufficient infiltration of immune cells into the tumor microenvironment (TME). This study ...
1Department of Oncology, Mayo Clinic, Rochester, Minnesota.
1Department of Radiation Oncology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas. 2Department of Biochemistry, The University of Texas Southwestern Medical Center at ...
1i3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. 2Faculdade de Medicina, Universidade do Porto, Porto, Portugal.
1Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.
Downregulation of the major histocompatibility complex class I (MHCI) is a mechanism of immune evasion associated with immune-cold tumors, like prostate cancer. Chesner and colleagues conducted a ...
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