Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics ...

Antibiotic resistance frequently results in delayed adequate antibiotic treatment, increasing morbidity and mortality. AMR is the inherited ability of microorganisms to grow at high antibiotic ...

Abscisic acid (ABA) prevents cotyledon opening in the dark by modulating splicing through serine/arginine-rich (SR) proteins RS40 and RS41. Light reduces ABA levels, releasing this repression to allow ...

Quiescence in melanoma is not a rare and static state but a dynamic and reversible condition accessible to most tumor cells, ...

Exhaustion of CD8 + T-cells leads to their reduced immune functionality and is controlled by numerous transcription factors. Here we show that the transcription factor IRF-5 helps to limit functional ...

Among the hundreds of proteins that are secreted by Legionella pneumophila (the causative agent of Legionnaires’ disease) during infection, the SidE class of effectors modify host proteins by ...

Brain metastasis (BM) remains a significant challenge in breast cancer (BC) management. While conventional metastatic routes primarily involve hematogenous dissemination, emerging evidence suggests ...

Hematopoietic stem and progenitor cells (HSPCs) polarize in contact with the bone marrow stromal cells constituting their niche. Given the role of cell polarity in protection against tumorigenesis and ...

imageimageThis study identifies Ki-67 as a critical modulator of the intensity of pro-inflammatory gene expression governing neutrophil recruitment during respiratory infections. The severity of ...

Macrophages not only clean the wound early for repair, but are also critically involved in all subsequent phases of proliferation and regeneration (Mirza et al, 2009; Shook et al, 2016).They ...

Oral leukoplakia (OLK) is the most prevalent oral potentially malignant disorder (OPMD) in clinical practice (Kerr and Lodi, 2021).Its prevalence is reported to be 0.5% to 3.46%, and its malignant ...

Histone posttranslational modifications (PTMs) such as ubiquitination, methylation and phosphorylation play a crucial role in gene transcription, DNA replication and repair (Chen and Tyler, 2022; ...