The 49ers opened their preseason with a 30-9 loss against the Denver Broncos from Levi's Stadium in Santa Clara, Calif. While there was some good and bad for the 49ers from the preseason opener, most fans just wanted a look at some of the fresh faces and for San Francisco to get out of the contest mostly in one piece.

The San Francisco 49ers opened their 2025 preseason slate at home, hosting the Denver Broncos at Levi's® Stadium. San Francisco's offense came out hot with a scoring drive on their first possession, but the Broncos ultimately pulled away in the second half to secure a 30-9 win.