RB Christian McCaffrey is expected to play vs. the Titans despite a questionable tag, with multiple NFL insiders signaling good news.

Overlooking the Tennessee Titans is incredibly enticing for the San Francisco 49ers to do. They’re arguably the worst team in the NFL, so beating them shouldn't

Our experts' predictions are in for Tennessee Titans vs. San Francisco 49ers on Sunday. Here's who our experts are picking to win the Week 15 NFL game.

The Tennessee Titans and the San Francisco 49ers meet Sunday in Week 15 in Santa Clara, California, with kickoff slated for 4:25 p.m. ET.

In the past month, they’ve faced three of the top four teams per defensive DVOA and averaged 22.6 points scored in those games. That’s good going when they’ve averaged just 15.5 points across the whole season. The 49ers are averaging 23.6 points per game, and with the Titans showing real signs of improvement, we should see the game total smashed.

USA Today's NFL experts make their picks for a Week 15 showdown between the San Francisco 49ers and Tennessee Titans

The San Francisco 49ers could face a major setback when the 2025 NFL season ends, as Robert Saleh might be on a team's radar for head coach.

Sunday’s game at Levi’s Stadium could get out of hand quickly. The San Francisco 49ers will host the Tennessee Titans as 12.5-point favorites in Week 15. The un

So if the Niners let him play out his contract, shake his hand, and watch him sign a solid $20-to-$30 (maybe $40) million-dollar deal elsewhere in free agency come the end of the 2026 season, the league office will essentially FedEx a third-round pick (fourth at worst) to Santa Clara. That’s money in the bank. That’s a free lottery ticket.