Uridine 5'-diphospho-glucuronosyltransferase (UDP -glucuronosyltransferase, UDPGT or UGT) is a microsomal glycosyltransferase (EC 2.4.1.17) that catalyzes the transfer of the glucuronic …

This review discusses recent advances in the understanding of the functional roles of UGT, their regulation and tissue expression, and clinical significant factors (ontogeny, interactions and …

All UGT genes that have been named by the committee and associated publicly available information are available for download. The latest publicly available UGT names and …

Jul 23, 2025 · UDP-glucuronosyltransferase (UGT) enzymes are a family of proteins that play an important role in the body’s detoxification processes. These enzymes are found predominantly …

UGT, or glucuronosyltransferase, is defined as a Phase II enzyme that facilitates drug metabolism by covalently adding a glucuronic moiety to drugs or endogenous compounds. The major …

Jan 15, 2025 · Human UDP-glucuronosyltransferases (UGTs) are pivotal phase II metabolic enzymes facilitating the transfer of glucuronic acid from UDP-glucuronic acid (UDPGA) to …

Feb 1, 2012 · The protein produced from the UGT1A1 gene, called the bilirubin uridine diphosphate glucuronosyl transferase (bilirubin-UGT) enzyme, is the only enzyme that …

The cytochrome P450 enzyme (in particular CYP3A4) is clearly the greatest contributor to drug metabolism for most medications. However, UDP-glucuronosyltransferase (UGT) enzymes are …

Nov 20, 2023 · In this study, we comprehensively analyzed the transcriptome of 22 UGTs in 54 human tissues/regions using RNAseq data from GTEx. We then validated the findings in the …

UDP-glucuronosyltransferase (UGT) is an enzyme that plays a critical role in the biotransformation and metabolism of various substances by catalyzing the process of …