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HIV can affect the nervous system and may contribute to nerve inflammation or damage, which can cause pain, burning, tingling, numbness, or weakness that may travel from the lower back or buttock down the leg—symptoms people often describe as “sciatica.” ⚠️ But not every case of sciatica in someone living with HIV is caused by HIV. Other causes include disc problems, spinal compression, infections, or other nerve conditions. If the pain is persistent, worsening, or associated with weakness or lo
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