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Understanding your MTHFR variant helps explain why symptoms like fatigue, anxiety, migraines, hormonal struggles, postpartum issues, and histamine sensitivity appear. MTHFR affects how your body activates folate into 5 MTHF, which supports methylation, detoxification, neurotransmitters, DNA repair, hormones, and energy. When this enzyme slows, your body needs higher levels of key nutrients, and this is where orthomolecular support becomes transformational. C677T variants tend to impact folate ac
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